miniPCR bio
TM
Learning Lab. BioBits
®
: Central Dogma
Version: 1.2 - Release July 2020 - © 2020 by miniPCR bio™
P./40
Instructor’s Guide
Standards alignment
Next Generation Science Standards alignment
Students who demonstrate understanding can:
HS-LS1-1.
Construct an explanation based on evidence for how the structure of DNA determines the structure
of proteins which carry out the essential functions of life through systems of specialized cells.
HS-LS3-1.
Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions
for characteristic traits passed from parents to offspring.
Science and Engineering
Practice
Disciplinary Core Ideas Crosscutting Concepts
•AskingQuestionsandDening
Problems
• Developing and Using Models
• Planning and Carrying Out
Investigations
• Analyzing and Interpreting Data
• Constructing Explanations and
Designing Solutions
• Engaging in Argument from
Evidence
• Obtaining, Evaluating, and
Communicating Information
LS1.A: From Molecules to Organisms: Structures
and Processes
•All cells contain genetic information in the form of
DNA molecules. Genes are regions in the DNA that
contain the instructions that code for the formation
of proteins, which carry out most of the work of
cells.(HS-LS1-1)
LS3.A: Inheritance of Traits
• Each chromosome consists of a single very long
DNA molecule, and each gene on the chromosome
is a particular segment of that DNA. The instructions
for forming species’ characteristics are carried in
DNA. All cells in an organism have the same genetic
content,butthegenesused(expressed)bythecell
may be regulated in different ways. Not all DNA
codes for a protein; some segments of DNA are
involved in regulatory or structural functions, and
somehavenoas-yetknownfunction.(HS-LS3-1)
• Patterns
• Cause and Effect
•Scale,Proportion,AndQuantity
• Systems and System Models
• Energy and Matter
• Structure and Function
• Stability and Change
• Interdependence of Science,
Engineering, and Technology
•InuenceofEngineering,
Technology, and Science on
Society and the Natural World
Common Core ELA/Literacy Standards
RST.9-10.1 Citespecictextualevidencetosupportanalysisofscienceandtechnicaltexts,attendingtothe
precise details of explanations or descriptions.
RST.9-10.3 Follow precisely a complex multistep procedure when carrying out experiments, taking measurements,
orperformingtechnicaltasks,attendingtospecialcasesorexceptionsdenedinthetext.
RST.9-10.4 Determinethemeaningofsymbols,keyterms,andotherdomain-specicwordsandphrasesastheyare
usedinaspecicscienticortechnicalcontextrelevanttogrades9-10textsandtopics
RST.9-10.5 Analyze the structure of the relationships among concepts in a text, including relationships among key
terms(e.g.,force,friction,reactionforce,energy).
RST.9-10.9 Compareandcontrastndingspresentedinatexttothosefromothersources(includingtheirown
experiments),notingwhenthendingssupportorcontradictpreviousexplanationsoraccounts.
WHST.9-10.1 Writeargumentsfocusedondiscipline-speciccontent.
WHST.9-10.2 Writeinformative/explanatorytexts,includingthenarrationofhistoricalevents,scienticprocedures/
experiments, or technical processes.
WHST.9-10.9 Drawevidencefrominformationaltextstosupportanalysis,reection,andresearch.
*For simplicity, this activity has been aligned to high school NGSS and grades 9-10 Common Core standards. This lab is easily
aligned to other grade levels as well.