Example 3
Pancreatic adenocarcinoma (PAAD) is the third leading cause of cancer deaths
in the USA and seventh worldwide. Older individuals are at a significantly
higher risk of developing PAAD, with 80% of PAAD tumors developing in
patients between the ages of 60 and 80 years. Since patients seldom exhibit
symptoms until advanced stages of the disease, the most significant challenge
in combating PAAD is detecting the disease in its early stages. There are
currently no proven markers for PAAD, making early diagnosis virtually
impossible. Recent studies have shown that the intratumoral microbiome may
play a role in the development of PAAD. We aim to identify dysbiotic microbes
between PAAD and normal samples and characterize their effects on immune
signaling that may alter PAAD carcinogenesis. This will be accomplished
through the mining and analysis of patient RNA-sequencing data using various
computational analyses that correlate between microbial abundance, host
gene expression, and clinical outcomes. We hypothesize that changes to the
microbiome over time as the host ages may lead to deleterious signaling that
leads to PAAD, and therefore may explain why age is such a significant risk
factor. We hope that our findings may eventually contribute to the
development of better immunotherapy strategies and diagnostic tools for
patients with PAAD, thereby improving the prognosis of these patients.