1.
Current use of immunosuppressive drugs such as adrenal
suppressive doses of corticosteroids, cyclosporine,
azathioprine, and other agents that carry an unacceptable risk
for increased infection or other significant adverse effects.
2.
History of primary immunodeficiency with symptoms frequent
enough to require continuing diagnostic evaluations, frequent
follow-up or medical care, treatment or therapy which, in the
judgment of the reviewing examiner, may limit geographic area
of assignment or may interfere with performance of duties.
3.
A reliable history of severe allergic reactions or anaphylaxis.
Anaphylaxis is highly likely when any one of the following
3 criteria are fulfilled:
•
Acute onset of an illness (minutes to several
hours) with involvement of the skin, mucosal
tissue, or both (e.g., generalized hives, pruritus or
flushing, swollen lips-tongue-uvula) and at least
one of the following:
▪
Respiratory compromise (e.g., dyspnea,
wheeze-bronchospasm, stridor, reduced
peak expiratory flow, hypoxemia).
▪
Reduced blood pressure (BP) or
associated symptoms of end-organ
dysfunction (e.g., hypotonia [collapse],
syncope, incontinence).
•
Two or more of the following that occur rapidly
after exposure to a likely allergen for the patient
(minutes to several hours):
▪
Involvement of the skin-mucosal tissue
(e.g., generalized hives, itch-flush,
swollen lips-tongue-uvula).
▪
Respiratory compromise (e.g., dyspnea,
wheeze-bronchospasm, stridor, reduced
peak expiratory flow, hypoxemia).
▪
Reduced BP or associated symptoms
(e.g., hypotonia [collapse], syncope,
incontinence).
▪
Persistent gastrointestinal symptoms
(e.g., crampy, abdominal pain,
vomiting).
•
Reduced blood pressure after exposure to known
allergen for that patient (minutes to several
hours):
▪
Infants and children: low systolic
BP (age-specific) or greater than
30 percent decrease in systolic blood
pressure.
▪
Adults: systolic BP of less than
90 mmHg or greater than 30 percent
decrease in from that person’s
baseline.